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 Neuraminidase Structure DB

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  PDB files

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influenzaA

  PDB files

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chicken

  PDB files

  Fasta


H5N1

  PDB files

  Fasta


chicken and H5N1

  PDB files

  Fasta


NADB BLAST


Citation:
Please cite the following reference in your presentation (conference, literature, press release, etc.) if you used the information in this database. Thank you.
Mayuko Takeda-Shitaka, Genki Terashi, Daisuke Takaya, Kazuhiko Kanou, Mitsuo Iwadate and Hideaki Umeyama, Protein structure prediction in CASP6 using CHIMERA and FAMS, Proteins, 61 Suppl 7, 122-127 (2005).


Nadb@gsc.riken.jp

 

 This database contains information on predicted three-dimensional structures of neuraminidase. Neuraminidase is a protein that is necessary for virus proliferation, which makes the protein an ideal target for the development of anti-influenza drugs. Homology modeling method of Full Automatic Modeling System, or FAMS (a system developed by Dr. Umeyama, Senior Visiting Scientist at RIKEN/Professor at Kitasato University), was used to predict the structures of the protein. This structural data have been made open to public to thwart a global pandemic by influenza. Neuraminidase is divided into 9 subtypes (N1 to N9). The database contains 1603 three-dimensional models of all subtypes of the protein.

 New Strain of Influenza 


 Devastating damage on poultry has been reported since the end of 2003 by the global outbreak of a new strain of toxic avian influenza virus. Cases on human infections have, also, been reported around the globe, and the number of fatalities is rising. Currently no case has been reported on a transmission of the new virus from a human host to another human. However, the threat of a new pandemic has been feared once the virus mutates/evolves to gain an ability to transmit between human.


 Predicting the Three-dimensional Structure of Neuraminidase a Potential Drug Target  


 Neuraminidase, a viral protein that regulates the proliferation of virus, is the most popular protein for the development of anti-influenza drugs. The prediction for the three-dimensional structure of the protein have been generated through a computational method call homology modeling. The result of the predictions has been stored in a database to provide a resource to respond against a potential influenza pandemic.


 Anti-influenza Drugs That Target Neuraminidase 


 Neuraminidase is a protein that regulates the release of virus from an infected cell. New infections are made through the release of progeny viruses from the infected cell that searches for a new host. Inhibiting the activity of neuraminidase will halt the spread of influenza virus. Neuraminidase inhibiting drugs that have been approved by the Japanese government are zanamivir (relenza) and oseltamivir phosphate (tamiflu).
Dissemination of the three-dimensional structure of neuraminidase is an imperative for the timely development of new drugs. Publicizing this database brings hope for the development of new drugs, a precaution against a potential pandemic.


 Search for Anti-influenza Compounds Through the Use of the Database 


 The Protein Research Group in RIKEN is actively using the data to search for chemical compounds that have potentials in becoming anti-influenza drugs. A method call in silico screening has been implemented for the sake to optimize the time it takes for the search to complete. This strategy will actively search for a new drug candidate, and will also contribute in the modification of currently available drugs.



last update : Jan 20, 2006




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