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Ongoing projects

  Platform for Drug Discovery, Informatics, and Structural Life Science  [>> web page (Japanese only)]

  YNMR - NMR Facility, Yokohama Institute, RIKEN  [>> web page]

  RIKEN Program for Drug Discovery and Medical Technology Platforms  [>> web page]

Finished projects

 

 This program maximally utilizes the results and research bases developed in the "National Project on Protein Structural and Functional Analyses" and the "Development of Advanced Technology for Protein Analysis". Protein targets of crucial importance for academic research and industrial applications that are intractable at the current technological level are selected in three research fields: investigation of fundamental biological phenomena, contribution to medical and pharmaceutical sciences, and industrial applications including food and environment. Structural and functional analyses of the proteins are performed, with the development of advanced protein production technology, advanced beamline and NMR technology, chemicals, and "information platform" technology.
Go to "Targeted Proteins Research Program, MEXT, Japan" page.

Faculty of Science, Hokkaido University
Faculty of Pharmaceutical Sciences, Hokkaido University
Graduate School of Agricultural and Life Sciences,The University of Tokyo
Institute of Materials Structure Science, High Energy Accelerator Research Org.
Graduate School of Science, Kyoto University
RIKEN / SPring-8
RIKEN GSC
Graduate School of Integrated Science,Yokohama City University
Institute for Protein Research, Osaka University
Graduate School of Science, Osaka University

  I. Program for comprehensive studies
  II. Program for focused studies
II-1.
Development/differentiation
and DNA replication/repair
II-2-1.
Transcription and translation
II-2-2.
Transcription and translation
II-3.
Posttranslational modification
and transport  
II-4.
Folding of higher-order structures of protein   
and expression of function
II-5.
Cellular signal transduction
II-6.
Brain and nervous system
II-7.
Metabolic system

  Japan is promoting structural genomics/proteomics projects. The first effort was conceptualized back in 1995, and began with the Protein Folds Project and the Structurome Project (the Whole Cell Project) at RIKEN in 1997. Launched in 2002, the National Project on Protein Structural and Functional Analyses (NPPSFA or the "Protein 3000" Project) was organized by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. Japan has made the analysis of protein structures and functions a top priority, with the Science and Technology Basic Plan, which is formulated every five years and presently indicates that the emphasis will be placed on "proteomics, the elucidation of protein structures or drug sensitive genes, and on new drug development based on this". As a result, NPPSFA has become Japan's biggest life sciences project.

 The project involves two programs and nine research centers: research laboratories at RIKEN (Program for comprehensive studies) and eight centers (Program for focused studies). The basic aim of the project is to obtain deep insight into the biological network by solving over 3000 protein structures and determining the functions of biological and medical importance. The research topics include investigating the three-dimensional structures and molecular functions, elucidating the molecular mechanisms of biologically and medically important phenomena, developing technologies suitable for large-scale structural biology studies, and discovering chemical compounds to control proteins, which would lead to rational drug design. It is estimated that the project results will form the foundations for biological, medical, and pharmaceutical research and will have a critical impact in supporting general life science research today. Strategic utilization of the research results, particularly in industrial applications such as drug development, is highly anticipated.

 A pipeline for high-throughput structure analyses has been established at each research center with the use of large-scale facilities for protein production and three-dimensional structural determinations (the synchrotron radiation facility, SPring-8 and Photon Factory for X-ray crystallography; and nuclear magnetic resonance (NMR) facilities at RIKEN Genomic Sciences Center, Yokohama City University, and Hokkaido University). According to the statistics obtained in October 2005, the project performed some 2,300 structural analyses. Various research techniques, including those for structure determination, NMR techniques (both software and hardware), automated robotic crystallization/observation systems, automated measurements of X-ray diffraction data, and cell-free protein production are being developed so as to achieve high-throughput analyses.


 This program upgrades the research facilities of the institutions to form research centers for emerging and reemerging infectious diseases, creates a framework for shared-use and joint research, and promotes integrated research beyond traditional fields, such as medical science and veterinary science. In addition, this program establishes overseas laboratories as bases for infectious disease research, expedites the accumulation of basic knowledge, and develops human resources to respond promptly for the assessment of emerging and reemerging infectious diseases through these actions.
Go to "Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases" page.

last update : Dec 20, 2012

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